Plants that qualify as industrial hemp, by the standards of the 2014 Farm Bill, must contain less than .3% THC. But the sale of hemp products is seemingly only permitted when derived from the stalks and seeds of the plant (as opposed to the flowers, where a lot of the good stuff is). Mix in the phenomenon known as the "entourage effect" — which demonstrates that CBD is most effective when used in combination with other cannabinoids, leading many to seek a "whole plant" or "full spectrum" version of the compound — and that's where it gets tricky. Are producers of hemp-derived CBD really only using stalks? Would that product be very effective? It remains unclear.
But, uh, what is it that CBD is supposed to do? I visited a cannabis dispensary in Boulder to find out what the hype was all about. After passing an ID check, I was introduced to a “budtender” who pointed me to an impressive array of CBD products — tinctures, skin patches, drink powders, candies, salves, massage oil, lotions, “sexy time personal intimacy oil” and even vaginal suppositories to treat menstrual cramps.
A colleague of Mechoulam’s, Marc Feldman at Imperial College, London, tested CBD on mice that had a version of rheumatoid arthritis. He found that CBD reduced the mice’s inflammation by 50% at the right dosage. Cardiologists working with the mice at Hebrew University have found that a dosage of CBD immediately following a heart attack can reduce infarct size by about 66%.
If made specifically from industrial hemp, hemp extract does not contain the cannabinoids CBD and THC, says Bissex. However, it may contain other cannabinoids and plant compounds that interact with our endocannabinoid system, which regulates our brain, immune, and hormone function. Through this system, hemp extract helps modulate our body’s response to stress and promote a sense of well-being. Harness your own endocannabinoid system and reap the benefits with a supplement like one of HempFusion‘s hemp extracts, now available at The Vitamin Shoppe.
The anti-inflammatory contributions of THC are also extensive, including inhibition of PGE-2 synthesis (Burstein et al 1973), decreased platelet aggregation (Schaefer et al 1979), and stimulation of lipooxygenase (Fimiani et al 1999). THC has twenty times the anti-inflammatory potency of aspirin and twice that of hydrocortisone (Evans 1991), but in contrast to all nonsteroidal anti-inflammatory drugs (NSAIDs), demonstrates no cyclo-oxygenase (COX) inhibition at physiological concentrations (Stott et al 2005a).
CBD’s action within the brain and body is quite complicated. To date, scientists have discovered more than a dozen different mechanisms of action, or ways that CBD affect us. It’s very likely that the beneficial effects of CBD are a result of the total of its activation of all of these biological pathways, not a single one in particular. Much more research is needed to fully understand the mechanisms by which CBD relieves ailments such as anxiety and seizures.

This is the story of our 5 year old Charlotte Figi. Charlotte suffered from Dravet Syndrome, a severe form of epilepsy found in children. From the time she was 2 she was having over 300 seizures a week which drastically affected her ability to learn, speak or even walk. She was unable to keep up with her twin sister. She was catatonic and nothing the doctors could do for her helped. All of their “medicines” had no effect on her condition and if anything they made her worse. Some of them almost killing her.After exhausting all other treatments, her we turned to the internet to see what alternative treatments may be available. To our surprise we found a certain strain of cannabis from Dr MARK DONALD (the strain was later named Charlottes Web in her honor) was specifically helping children with Dravet Syndrome. So we made the decision to give cannabis oil to Charlotte and from the first dose we noticed results. The 300+ seizures she was experiencing each week was reduced to only 1. we have been amazed with the results and are so happy to get our daughter back . All thanks goes to Dr Mark Donald for providing us with the Cannabis Oil. WE VOTE FOR DR MARK DONALD 100%
What are some statistics from research of long-term use of CBD oil when used for chronic pain? How does this unregulated supplement effect our bodies when used over the course of, for example, one or more years? Just because something is natural does not make it safe for human consumption, especially for daily use over the course of many months/years. I’m not trying to put a negative spin on CBD oil but am cautiously optimistic…cautious being the operative word here because I (like many others here) have tried soooo many alternative therapies before finding that opioids work for me to control my chronic pain after 2 spinal fusions, degenerative disc disease effects, , osteoarthritis effects, carpal tunnel syndrome wear and tear, a broken sternum, 2 broken thoracic vertebrae and 2 spinal compression fractures. CBD oil purchase will likely not be reimbursed by insurance companies because it is not FDA approved and, therefore, our government cannot profit from its cultivation, processing and sales.
^ Jump up to: a b c d Campos AC, Moreira FA, Gomes FV, Del Bel EA, Guimarães FS (December 2012). "Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders". Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences (Review). 367 (1607): 3364–78. doi:10.1098/rstb.2011.0389. PMC 3481531. PMID 23108553.
Scott Shannon, M.D., assistant clinical professor at the University of Colorado, recently sifted through patient charts from his four-doctor practice to document CBD’s effects on anxiety. His study, as yet unpublished, found “a fairly rapid decrease in anxiety scores that appears to persist for months,” he says. But he says he can’t discount a placebo effect, especially since “there’s a lot of hype right now.”
Hemp oil can come from the flower, leaves, stock or seeds. If it comes from the seed there are no cannabinoids found. If it comes from the rest of the plant cannabinoids are found. Hemp extract usually refers to either CBD or oil from the stock, flower, or leaves. Our Virgin cannabis sativa hemp oil is a hemp seed oil, and our Premium hemp oil products, have hemp oil from the stem of the plant (which is listed in milligrams on the bottle) It also has hemp seed oil in the bottle to act as a carrier oil. Our Hemp seed oil is a cold pressed seed oil, and our Premium hemp oil that comes from the stem is Co2 extracted.

Chronic pain wears on your nerves. It is common for patients to experience severe anxiety. Historically, patients have been prescribed benzodiazepines (Valium and Xanax) to deal with this problem. Unfortunately, the combination of narcotics and benzos has led to increased overdose deaths. During our study it was clear that our patients experienced less anxiety. Instead of reaching for a friend’s benzo or alcohol to deal with their anxiety, they instead started reaching for their CBD oil.


I don’t have chronic pain exactly but I’ve been waking up with back pain for the past several years, from some unknown cause… maybe how I’m sleeping or I’m just getting old or something. I decided to try CBD oil since I’ve been hearing so much about it, I take it before bed and not only do I sleep better now but I also don’t wake up with pain anymore. It’s great. I guess it relaxes my muscles or something so they don’t end up becoming tight overnight? I have no idea but hey if it works it works.
There's plenty of anecdotal evidence that CBD helps treat a variety of ailments. People are turning to oils, gummies, and other CBD food and drink products to relax at the end of a long day. Retired NFL players are using CBD to manage physical pain, debilitating headaches, and sleeplessness. Spa clients are even using CBD skin products to fight signs of aging.
A review published in 2017 in the journal Frontiers in Pharmacology described how CBD may work to protect the hippocampus — the part of the brain responsible for several important functions, such as learning, memory and navigation — during times of stress, and may also help prevent brain-cell destruction that results from schizophrenia. Another 2017 review published in the journal Annals of Palliative Medicine summarized a handful of studies that suggest cannabis oils containing THC or CBD, or both, may help with chronic pain management, but the mechanism is unclear.
CBD Isolate is the purest supplement available. It’s a 99% pure CBD supplement derived from hemp oil. Despite its concentration, CBD isolate effects are similar to other CBD concentrates, and it can be used in a variety of ways. It can be consumed itself, added to foods and beverages, or vaporized. You can also add it to other CBD products to increase their potency.

As more and more states legalize the use of marijuana, a product known as CBD oil has surged in popularity. A chemical compound found in the cannabis plant, CBD, or cannabidiol, is non-intoxicating and does not cause the noticeable euphoric effects associated with tetrahydrocannabinol (or THC, another marijuana compound). Products marketed as CBD oil may contain THC.
Yes! when cold turkey no choice pulled off opiates when cancer returned I turned to medical marijuana! Yes I call it what it is because it saved my life in many ways, believe me I never thought could smoke it because anxiety/paranoid but it’s not true! It’s about educating yourself on the strains and different plants! No one plant is made the same. I highly recommend the Indica now it is known to be best for night because it does put you out as well as that pain! I have cut my Xanax in half! Indica is the one that will make you more relaxed and sleepy but talk about pain relief! also helping with sleep and anxiety! Sativa is your uplifting the happy type more to the head type plant, it will deliver some pain relief depending on which Sativa plant – it will deliver but this strain is known for weight loss, helps with depression, however it can on some plants trigger the anxiety people talk about – you would need to get the plant name and look up medical benefits then side effects, there is sites on this. I studied this plant very thorough before I ever began it. I choose the whole plant with THC – I hate it gets demonized, the THC has around 15 medical benefits. It gets demonized because like a opiate you can get mind altered – well the way I see it .. why is it so sinister to feel good when I live in hell of cancer pain. THC is a killer anti inflammatory! It is 1,000 more strong than aspirin and 100 times more strong than hydrocodone as far as anti inflammatory!!! which is essential for cancer and pain as well. Even an FDA-approved trial in 2013 confirmed THC’s effectiveness for pain relief. Individuals experiencing neuropathic pain were given low doses of THC (1.29%) in the form of vaporized cannabis. The results? “A low dose of delta-9-tetrahydrocannabinol provided statistically significant 30% reductions in pain intensity when compared to placebo.”While clinical research continues to be restricted due to cannabis’s regretful status as a !I controlled!!!
The glutamatergic system is integral to development and maintenance of neuropathic pain, and is responsible for generating secondary and tertiary hyperalgesia in migraine and fibromyalgia via NMDA mechanisms (Nicolodi et al 1998). Thus, it is important to note that cannabinoids presynaptically inhibit glutamate release (Shen et al 1996), THC produces 30%–40% reduction in NMDA responses, and THC is a neuroprotective antioxidant (Hampson et al 1998). Additionally, cannabinoids reduce hyperalgesia via inhibition of calcitonin gene-related peptide (Richardson et al 1998a). As for Substance P mechanisms, cannabinoids block capsaicin-induced hyperalgesia (Li et al 1999), and THC will do so at sub-psychoactive doses in experimental animals (Ko and Woods 1999). Among the noteworthy interactions with opiates and the endorphin/enkephalin system, THC has been shown to stimulate beta-endorphin production (Manzanares et al 1998), may allow opiate sparing in clinical application (Cichewicz et al 1999), prevents development of tolerance to and withdrawal from opiates (Cichewicz and Welch 2003), and rekindles opiate analgesia after a prior dosage has worn off (Cichewicz and McCarthy 2003). These are all promising attributes for an adjunctive agent in treatment of clinical chronic pain states.

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