I'm reading this in disbelief. I feel kind of numb to be honest. I'm in collection for thousands because of all the medical treatments, surgeries, and travel. For nearly 8 years my wife has worked two and sometimes 3 jobs and every time I was well enough I worked two jobs trying to catch up and still we fell behind. Call it pride or stupidity, but we never asked for help of any kind. I take care of older neighbors and spend much of my free time working with disabled veterans. I feel like I've given everything I had to help others my whole life. Thank You one and all!
The FDA relies on applicants and scientific investigators to conduct research. Our role, as outlined in the Federal Food, Drug, and Cosmetic Act, is to review data submitted to the FDA in a marketing application to determine whether a proposed drug product meets the statutory standards for approval. Additional information concerning research on the medical use of marijuana is available from the National Institutes of Health, particularly the National Cancer Institute (NCI) and NIDA.
I have dealt with overall muscle pain for several years and was finally diagnosed with fibromyalgia 6 months ago. Due to stomach issues, I am no longer able to take NSAIDs, and I don’t want to start down the opioid trail, so I’ve been pretty miserable. Most days I felt like I’d been hit by a truck, and by the end of a work day, I was done. Many evenings I had to use a foam roller on my neck, back, and legs before I could even think of going to bed, and just trying to sit and relax was sometimes impossible. My husband did a lot of research on CBD oil, and Medterra seemed to be a solid company with a good following. He got me a bottle of the 1,000mg tincture, and I “front-loaded” with two doses a day for the first 5 days, then went down to one 1ml dose each morning. Even though we were on a lake vacation and I was climbing in and out of the boat and bouncing around the lake, I noticed that the pain and achiness in my arms and legs was gone within the first couple of days. After a couple more days, I realized that the pain and tightness in my upper back/neck were nearly gone as well. I’m starting to get my “old” energy back, and I can focus on doing what I want to do without the pain constantly interfering. My next order will be for the 3,000mg tincture... I want to play with the dosing a bit and see if I can get some relief with lower back pain (unrelated to the fibro). If you’re dealing with muscle pain, I highly recommend giving Medterra CBD oil a try.
Various strains of "medical marijuana" are found to have a significant variation in the ratios of CBD-to-THC, and are known to contain other non-psychotropic cannabinoids. Any psychoactive marijuana, regardless of its CBD content, is derived from the flower (or bud) of the genus Cannabis. Non-psychoactive hemp (also commonly-termed industrial hemp), regardless of its CBD content, is any part of the cannabis plant, whether growing or not, containing a ∆-9 tetrahydrocannabinol concentration of no more than 0.3% on a dry-weight basis. Certain standards are required for legal growing, cultivating, and producing the hemp plant. The Colorado Industrial Hemp Program registers growers of industrial hemp and samples crops to verify that the dry-weight THC concentration does not exceed 0.3%.
Cannabidiol can be taken into the body in multiple different ways, including by inhalation of cannabis smoke or vapor, as an aerosol spray into the cheek, and by mouth. It may be supplied as CBD oil containing only CBD as the active ingredient (no added THC or terpenes), a full-plant CBD-dominant hemp extract oil, capsules, dried cannabis, or as a prescription liquid solution. CBD does not have the same psychoactivity as THC, and may affect the actions of THC. Although in vitro studies indicate CBD may interact with different biological targets, including cannabinoid receptors and other neurotransmitter receptors, the mechanism of action for its possible biological effects has not been determined, as of 2018.
If you are living with chronic pain, hemp offers you hope. CBD can be purchased online or over the counter in many forms in every state in the U.S., and many places around the world. The good news is CBD has a very broad safety profile, and you should feel comfortable trying it. Dosing is going to be a key, and we’ll discuss that in a later column. Taking too much won’t harm you, but it might not help you either. Please be sure to talk to your physician about CBD. In my next column, I will offer some tips for having this conversation, particularly if you feel awkward about cannabis or hemp, or suspect your doctor might react badly to your interest.
Devinsky puts more weight behind the scientific advancements: In June, the FDA approved an epilepsy drug called Epidiolex, which contains a purified form of CBD oil. In controlled clinical trials, the drug was proven to reduce seizures in people with Dravet syndrome and Lennox-Gastaut syndrome — and it didn't produce as many of the unpleasant side-effects that come with other epilepsy medications.
This is the story of our 5 year old Charlotte Figi. Charlotte suffered from Dravet Syndrome, a severe form of epilepsy found in children. From the time she was 2 she was having over 300 seizures a week which drastically affected her ability to learn, speak or even walk. She was unable to keep up with her twin sister. She was catatonic and nothing the doctors could do for her helped. All of their “medicines” had no effect on her condition and if anything they made her worse. Some of them almost killing her.After exhausting all other treatments, her we turned to the internet to see what alternative treatments may be available. To our surprise we found a certain strain of cannabis from Dr MARK DONALD (the strain was later named Charlottes Web in her honor) was specifically helping children with Dravet Syndrome. So we made the decision to give cannabis oil to Charlotte and from the first dose we noticed results. The 300+ seizures she was experiencing each week was reduced to only 1. we have been amazed with the results and are so happy to get our daughter back . All thanks goes to Dr Mark Donald for providing us with the Cannabis Oil. WE VOTE FOR DR MARK DONALD 100%
Hi Lauren I've just started today with 250mg cbd oil. I'm starting low to see what happens. I've nerve damage across buttocks from a laminectomy. I've not been able to sit for 5 years. I've recently started with a muscle spasm in my left buttock and the muscle above is painful. It is only the first day, also tried a cbd night time tea as well. Do change in muscle pain so tight on my left hand side. How long before felt it starting to work please. I'm trying not to expect changes straightaway. I also take 1100mg gabapentin and 30mg amitriptyline and I hate both of them - they both can cause muscle tightness affecting the nerve. Thank you Lyn
Research suggests that CBD may exert some of its pharmacological action through its inhibition of fatty acid amide hydrolase (FAAH), which may in turn increase the levels of endocannabinoids, such as anandamide, produced by the body. It has also been speculated that some of the metabolites of CBD have pharmacological effects that contribute to the biological activity of CBD.
Concerns are frequently noted with new drug-drug interactions, but few have resulted in Sativex RCTs despite its adjunctive use with opiates, many other psychoactive analgesic, antidepressant and anticonvulsant drugs (Russo 2006a), possibly due to CBD ability to counteract sedative effects of THC (Nicholson et al 2004). No effects of THC extract, CBD extract or Sativex were observed in a study of effects on the hepatic cytochrome P450 complex (Stott et al 2005b). On additional study, at 314 ng/ml cannabinoid concentration, Sativex and components produced no significant induction on human CYP450 (Stott et al 2007). Thus, Sativex should be safe to use in conjunction with other drugs metabolized via this pathway.
I have found after trying several different brands, MedTerra is the most potent, consistent and competitively priced product on the market. Being able to purchase it by mail order is also very convenient. One thing I noticed on other brands is there seems to be confusion over the actual dosage. Folks see 500 mg on the bottle and think they are taking a 500 mg dose. Incorrect! That is the total mg CBD per bottle. One brand for example states on the 2 oz bottle, 60ml-500mg. That breaks down to 8.333mg per ml. But it was only 60% purity which translates to only 5 mg per 1 ml dose. (500mg / 60 ml = 8.3333 mg per ml, at 60 % purity 8.3333 * .6 = 5 mg per ml dose.) I have not seen anyone break it down correctly until I looked at MedTerra. They dont mess around. You get 99% pure product, period. This allows more accurate dosage than other companies, giving YOU more control and confidence using their products. Pain and inflammation greatly reduced, I sleep better, mood and blood sugar leveled out, reduced appetite. Thank you MedTerra! Word of mouth is the best advertisement! All CBD Tinctures, regardless of strength, are 1 fluid oz and contain 30 servings at 1 ml each. The dropper in the cap has measurement markers of .25, .5, .75 and 1 ml to help with serving size. Here is the breakdown by strength of the amount of CBD per serving, 1 dropper full: 500mg contains 16mg of CBD per serving 1000mg contains 33mg of CBD per serving 3000mg contains 100mg of CBD per serving
What exactly is cannabidiol (CBD) and more importantly, what does it do? Those questions and more are at the heart of this comprehensive guide to one of the most fascinating and important compounds of the cannabis plant. Cannabis plants are chemical powerhouses that produce more than 400 different compounds. Not all of those compounds are unique to marijuana, of course, and appear in many other species of plants. That’s why marijuana can smell like pine trees or taste like fresh lemons. But of those 400 compounds, more than 60 of them are totally specific to the plant genus Cannabis. Scientists call these special compounds “cannabinoids.” However, not all cannabinoids are created equal. One of them, cannabidiol, or CBD, holds the key to the wide variety of medicinal and therapeutic effects marijuana offers.
The stark fact that hemp oil comes from cannabis plant, which is immensely controversial in many countries of the world because of its psychoactive capabilities has led to significant masking of data regarding hemp oil. Most countries now have regulations set in to determine what deserves to be called hemp oil. There is often a cap on the highest detectable limit of THC in hemp oil.
The glutamatergic system is integral to development and maintenance of neuropathic pain, and is responsible for generating secondary and tertiary hyperalgesia in migraine and fibromyalgia via NMDA mechanisms (Nicolodi et al 1998). Thus, it is important to note that cannabinoids presynaptically inhibit glutamate release (Shen et al 1996), THC produces 30%–40% reduction in NMDA responses, and THC is a neuroprotective antioxidant (Hampson et al 1998). Additionally, cannabinoids reduce hyperalgesia via inhibition of calcitonin gene-related peptide (Richardson et al 1998a). As for Substance P mechanisms, cannabinoids block capsaicin-induced hyperalgesia (Li et al 1999), and THC will do so at sub-psychoactive doses in experimental animals (Ko and Woods 1999). Among the noteworthy interactions with opiates and the endorphin/enkephalin system, THC has been shown to stimulate beta-endorphin production (Manzanares et al 1998), may allow opiate sparing in clinical application (Cichewicz et al 1999), prevents development of tolerance to and withdrawal from opiates (Cichewicz and Welch 2003), and rekindles opiate analgesia after a prior dosage has worn off (Cichewicz and McCarthy 2003). These are all promising attributes for an adjunctive agent in treatment of clinical chronic pain states.