Buying online is less reliable still because there’s no regulation or standardization. What you see on the label may not be what you are getting. A 2017 study in JAMA found that of the 84 CBD products researchers bought online, 43% had more CBD than indicated, while 26% had less, and some had unexpected THC. “There’s a 75% chance of getting a product where the CBD is mislabeled,” says Marcu, one of the study’s coauthors.
Here’s a mind-blowing example: a study in 2014 found that people with THC in their systems were 80 percent less likely to die from traumatic head injuries than those without. THC is great for Insomnia “Indica” Recent research suggests it may also improve breathing while reducing sleep interruptions. Great news for those suffering from conditions such as sleep apnea! Fact, studies have confirmed that THC eases a variety of PTSD-related symptoms including agitation, depression, insomnia, flashbacks, and nightmares. Not only does the psychoactive protect brain cells, it also stimulates brain growth. Researchers have found that THC interacts with the same type of receptors in the hypothalamus that release the hormone ghrelin, which stimulates hunger. In fact, THC can even make food taste better. Interestingly, certain cannabis cultivars can also suppress appetite, which can be another advantage for a lot of people – weight loss. Enhances Senses! In 2008, researchers at MIT discovered that treating a concerning antibiotic-resistant pathogen with the psychoactive successfully killed the bacteria when other drugs could not even MRSA! As a potent antioxidant, one of the many health benefits of THC is protecting the body from stress-related damage. A known bronchodilator, studies conducted back in 1975 provided the first evidence of the cannabinoid’s ability to ease asthma attacks. While multiple cannabinoids show anti-cancer potential, THC is one of the main contenders! THC is a muscle relaxant on its own, the molecule’s ability to ease cramps and tension is a plus. THC also has anticonvulsant properties. Continuing 1 more time…
HoneyColony and its materials are not intended to treat, diagnose, cure or prevent any disease. All material on HoneyColony is provided for educational purposes only. Always seek the advice of your physician or another qualified healthcare provider for any questions you have regarding a medical condition, and before undertaking any diet, exercise or other health related program.

Multiple sclerosis (MS). A prescription-only nasal spray product (Sativex, GW Pharmaceuticals) containing both 9-delta-tetrahydrocannabinol (THC) and cannabidiol has been shown to be effective for improving pain, muscle-tightness, and urination frequency in people with MS. This product is used in over 25 countries outside of the United States. But there is inconsistent evidence on the effectiveness of cannabidiol for symptoms of multiple sclerosis when it is used alone. Some early research suggests that using a cannabidiol spray under the tongue might improve pain and muscle tightness, but not muscle spasms, tiredness, bladder control, mobility, or well-being and quality of life in patients with MS.


The average dose range is 10-50 mg of CBD, one to three times per day, though much higher doses of 100-200 mg (sometimes required to control pain) are equally well tolerated. Some people will notice benefit at the lower end of the dose range, but most people will need 15-30 mg to notice any effects. Because different products provide different concentrations of CBD, the packaging usually states how much CBD is in the entire bottle as opposed to the amount in a certain number of drops or dropperfuls, so measuring can be a little tricky.
One thing that is important for you to remember is that it is best if you purchase pure CBD oil for sale. There are many products that add such things as vanilla extract, coconut extract, or other kinds of products to enhance flavor or smell. If you like those things that is perfectly fine to use, however if you are looking for the maximum strength type of relief, then the peer extract is really what you should be searching for.

It's important to know that although THC and CBD are the most studied components of cannabis, there are many more chemical compounds found within the plant, such as cannabigerol (CBG), cannabichromene (CBC), cannabidivarin (CBDV), tetrahydrocannabivarin (THCV), terpenes, and flavonoids. While there is still much to learn about these other chemicals, researchers in Israel have discovered that whole-plant cannabis extracts that contain these other chemicals are more beneficial than isolated extracts that contain just CBD or THC.
NIDA provides research-grade marijuana for scientific study. The agency is responsible for overseeing the cultivation of marijuana for medical research and has contracted with the University of Mississippi to grow marijuana for research at a secure facility. Marijuana of varying potencies and compositions is available. DEA also may allow additional growers to register with the DEA to produce and distribute marijuana for research purposes.
Although both oils are generally safe for use, the main difference between hemp oil and marijuana oil comes down to the THC content, which contributes to their different side effects. Marijuana’s THC content naturally contributes to more potential side effects related to memory, learning, and general cognition, which invariably means you shouldn’t be doing anything important, operating heavy machinery, or driving after taking marijuana oil. By comparison, hemp oil has far fewer side effects. Most side effects are related to hemp oil’s high polyunsaturated fat content, which may contribute to heart disease and digestive problems, but only if you are ignoring serving recommendations.
What a great article on CBD oils which only touches the surface of its benefits!! Only thing I disagree upon is it mentions CBD not containing any psychotropics. CBD oil requires a touch of THC to properly work. If the solution is strong enough and people take more than necessary one can get s little “high” for reals. A tiny amount of CBD oil goes a long way, especially when you have the oils directly produced from squeezing the oils from CBD prominent plants. Sativa plants often have a higher THC component than Indica plants and Sativa plants are smoked for their “get up and go properties “ rather than the more relaxing kick back Indica plants
Cannabis flavonoids in whole cannabis extracts may also contribute useful activity (McPartland and Russo 2001). Apigenin inhibits TNF-α (Gerritsen et al 1995), a mechanism germane to multiple sclerosis and rheumatoid arthritis. Cannflavin A, a flavone unique to cannabis, inhibits PGE-2 thirty times more potently than aspirin (Barrett et al 1986), but has not been subsequently investigated.
Concerns are frequently noted with new drug-drug interactions, but few have resulted in Sativex RCTs despite its adjunctive use with opiates, many other psychoactive analgesic, antidepressant and anticonvulsant drugs (Russo 2006a), possibly due to CBD ability to counteract sedative effects of THC (Nicholson et al 2004). No effects of THC extract, CBD extract or Sativex were observed in a study of effects on the hepatic cytochrome P450 complex (Stott et al 2005b). On additional study, at 314 ng/ml cannabinoid concentration, Sativex and components produced no significant induction on human CYP450 (Stott et al 2007). Thus, Sativex should be safe to use in conjunction with other drugs metabolized via this pathway.
I have a slightly bulging disc in my back that has been causing neuropathy in my left leg for years. I’ve had several rounds of trigger point injections; see a physical therapist regularly, and lately a chiropractor as well. The next step for me would be to try an epidural pain block. Several of my other doctors are big proponents of the “inflammation as a cause of disease” theory and have really encouraged me to do things to reduce inflammation. Omega-3 fatty acids in particular help with this (as most Americans consume a poor ratio of omega-6 to omega-3 which can increase inflammation.) Hemp products contain phytocannabinoids, a substance that can help decrease pain and inflammation. This is full spectrum hemp oil derived from hemp seeds—meaning it contains all of the phytocannabinoids and not just one in particular. This is NOT CBD (cannabidiol) oil, although based on my research it likely contains low levels of CBD. CBD is the substance produced from hemp flowers (a plant with little to no THC—the substance that causes a high) (or marijuana flowers—a plant in the same family with significant THC) that is widely known to have medicinal purposes in pain relief, stopping seizures, etc.

The existence of substantial clinical investigations regarding CBD has been made public. For example, two such substantial clinical investigations include GW Pharmaceuticals’ investigations regarding Sativex and Epidiolex. (See Sativex Commences US Phase II/III Clinical Trial in Cancer Pain and GW Pharmaceuticals Receives Investigational New Drug (IND) from FDA for Phase 2/3 Clinical Trial of Epidiolex in the Treatment of Dravet Syndrome ).

At Vertly, we believe in the healing power of plants – particularly in the form of our all natural Relief Lotion, a restorative, vitamin-packed lotion featuring our signature CBD. Use whenever you’re in need of a little self-care, self-love and relief from the aches of exercise, travel or life in general. Our concentrated Relief Lotion offers the benefits of rich organic plant oils, nourishing Shea butter, healing magnesium and botanical herbs like Arnica Flower, all packaged within the calming scent of citrus and lavender. The result? Skin that is soothed, hydrated and refreshed. A body that feels good from the outside in. Use all over or as a spot treatment for immediate relief and proceed to soothe yourself.
Schizophrenia. Research on the use of cannabidiol for psychotic symptoms in people with schizophrenia is conflicting. Some early research suggests that taking cannabidiol four times daily for 4 weeks improves psychotic symptoms and might be as effective as the antipsychotic medication amisulpride. However, other early research suggests that taking cannabidiol for 14 days is not beneficial. The conflicting results might be related to the cannabidiol dose used and duration of treatment.
We are sorry our blog post didn’t answer the question you were looking for. The answer to your question is, that the best product that can assist with chronic pain is a product that contains Cannabinoids in it. Full spectrum hemp oils contain those cannabinoids your body needs to fight pain, stress, anxiety, inflammation and sleep. If your chronic pain is severe, you will want a product that contains a large amount of Cannabinoids.

14. In making the two previous determinations about THC, why did FDA conclude that THC is an active ingredient in a drug product that has been approved under section 505 of the FD&C Act? In making the two previous determinations about CBD, why did FDA determine that substantial clinical investigations have been authorized for and/or instituted, and that the existence of such investigations has been made public?
The nervous system’s endocannabinoid system is not well understood. But it’s thought to play a role in regulating pain, sleep, mood, memory, appetite, and other cognitive and physical processes. Because CBD is able to mimic the actions of some natural brain chemicals, its potential therapeutic benefits are wide-ranging but—at this point—nebulous. “We know that cannabidiol modulates the endocannabinoid system, but we don’t know how it works,” Szaflarski says. That said, there are theories.

Unlike THC, which primarily binds to CB-1 receptors located in the brain, CBD works in the body by manipulating receptors throughout organ tissues, the immune system, the pain response system, the hormonal system, and other whole-body regulatory systems. Basically, since its receptors have been found to exist in virtually every cell and tissue type in the body, CBD is believed to work on every aspect of human health and behavior – from the subcellular level to the whole-body leve and beyond.


I used to treat a student with a very aggressive seizure disorder. It was so aggressive, I couldn’t turn the lights on or off in our room while she was there or it could trigger a grand mal seizure. I was talking to her mother on the phone about her progress one day and she confided in me that she’d started using hemp oil, rubbing it on her daughter at night, and that she hadn’t had a seizure since. I was happy to hear.
Success stories like Oliver’s are everywhere, but there’s not a lot of data to back up those results. That’s because CBD comes from cannabis and, like nearly all other parts of the plant, is categorized by the Drug Enforcement Agency (DEA) as a Schedule 1 drug—the most restrictive classification. (Others on that list: heroin, Ecstasy, and peyote.) This classification, which cannabis advocates have tried for years to change, keeps cannabis-derived products, including CBD, from being properly studied in the U.S.
Individuals with sleep disorders are likely to experience more intense pain as the body is unable to complete its natural healing process to alleviate some of the effects caused by arthritis, fibromyalgia, muscle injury, or other type of chronic pain. The danger with chronic pain is that it keeps the nerves engaged in a fight-or-flight state, which makes it extremely difficult to relax and fall asleep. CBD has neuroprotective properties that encourage rest and improve sleep.

There have been no reports of anyone overdosing on cannabis. One of the unique properties of the chemical components of cannabis, including both hemp and marijuana, is that they don’t cause respiratory or cardiac depression. This sets even recreational use of cannabis widely apart from narcotics and alcohol, both of which can cause severe respiratory depression and death at excessive doses. Excessive doses of hemp, and more especially, marijuana, may make you very agitated and feel terrible, but there are no known deaths from cannabis overdose.
One of the main benefits of using CBD for pain relief is the fact that it doesn’t cause the same dependency that people get from using pharmaceutical pain medication. People have been looking into alternative pain medication for a long time – in fact plant-based treatments such as turmeric and frankincense have been used for a long time as natural therapies for pain. Cannabidiol is one such treatment that has a long history as a pain medication. Only recently the medical sector has acknowledged its use as a legitimate treatment for a variety of ailments including chronic pain.

There’s no definite amount that’s appropriate for everyone, but the ratio of CBD to THC will indicate how psychoactive the product is and if it’s legal in your state. The more CBD compared with THC, the less of a high, and vice versa. “Managing psychoactivity is key to successful cannabis therapy,” says Lee. “Amounts should be made clear on the label and lab-certified so people know what’s helping them and what’s not.”
There are two preventative procedures you should be taking if you want to keep your skin as youthful for as long as possible: wear sunscreen and wear anti-aging cream at night. Unfortunately, I couldn’t source a reputable sunscreen with CBD, so you’ll have to trust me on the face cream, instead. This organic hemp CBD—sourced from Colorado—and vitamin E oil-enriched formula is too rich for daytime use (unless you have very dry skin and you don’t live in a humid climate), but it’s the perfect luxe treatment to massage into your face and neck before bed every night. After a week of wearing this cream every night, I, a very cystic acne-prone person, did not have any breakouts and had noticeably softer skin in the morning.
CBD IS AN ABBREVIATION FOR CANNABIDIOL, A CHEMICAL COMPOUND FOUND NATURALLY IN THE HEMP PLANT. IT IS NOT MIND ALTERING LIKE MARIJUANA, WHICH MEANS CBD CREAM WILL NOT MAKE YOU HIGH. OVER THE PAST 40 YEARS THERE HAVE BEEN NUMEROUS STUDIES THAT HIGHLIGHT THE POTENTIAL OF CBD. RESEARCHERS DISCOVERED THE HUMAN ENDOCANNABINOID SYSTEM (ECS), WHICH IS THE SYSTEM THAT CBD INTERACTS WITH.
CBD’s action within the brain and body is quite complicated. To date, scientists have discovered more than a dozen different mechanisms of action, or ways that CBD affect us. It’s very likely that the beneficial effects of CBD are a result of the total of its activation of all of these biological pathways, not a single one in particular. Much more research is needed to fully understand the mechanisms by which CBD relieves ailments such as anxiety and seizures.

It’s also important to select CBD oil products based on your concentration preferences. Some forms of CBD oil – such as vapors and tinctures – normally have higher-than-average concentrations, whereas sprays and topicals tend to have lower concentrations. Remember: higher concentration means more pronounced effects, but not necessarily mean higher quality.
Historically, hemp could legally be grown and cultivated for academic research purposes only. However, the legality of hemp growth has changed in the past year. In April 2018, Sen. Mitch McConnell of Kentucky introduced the Hemp Farming Act of 2018, a piece of legislation that proposed legalizing all hemp products at the federal level. The act was incorporated in the 2018 United States Farm Bill, which passed in both the House and Senate in December 2018. Per the farm bill, industrial hemp will be descheduled as a federally controlled substance.
This is true despite the fact that unlike marijuana, hemp contains only trace levels of THC (tetrahydrocannabinol), the chemical component that gives marijuana its euphoric qualities. Instead, hemp is primarily known for its fibers, commonly used to make rope, fabrics, auto parts, industrial materials, and a variety of other products. Hemp is also known for its highly-nutritious seeds (a.k.a. hemp hearts), which have been shown to benefit heart health, skin diseases, and more.
I purchased this product locally and as I walked back to my car, I was in so much pain in my feet and hands I wasnt sure I could make it back. I sat in my car and took a dropper full (1ml). As I was sitting there I could feel the inflammation in my hands disappear and the pain went away. My feet began to feel the effects next and the pain all but subsided. I hadnt been sleeping very good at night but last night I slept like a baby with NO pain. Why isnt this marketed as a product that is NON opiod and covered by insurance? Rheumatoid Arthritis is the most painful thing in the world but this helped me 100%. I almost cried last night I was so happy for a change! Thank you for making this product.
They may be safe, but there's one massive problem: There's practically no scientific data to support the idea that a CBD-infused topical cream is any more effective than other topical pain relievers, like Tiger Balm, BenGay, or Icy Hot. Michelle Sexton, a San Diego-based naturopathic doctor and medical research director of the Center for the Study of Cannabis and Social Policy says that her patients do seem to have a great interest in CBD ointments, and roughly 40 percent of them have indeed tried one. However, these people are in her office now because the topicals didn’t work for them. "As a medical professional, my opinion is there’s little evidence to back up the claims being made—it’s all marketing for now," she says.
The glutamatergic system is integral to development and maintenance of neuropathic pain, and is responsible for generating secondary and tertiary hyperalgesia in migraine and fibromyalgia via NMDA mechanisms (Nicolodi et al 1998). Thus, it is important to note that cannabinoids presynaptically inhibit glutamate release (Shen et al 1996), THC produces 30%–40% reduction in NMDA responses, and THC is a neuroprotective antioxidant (Hampson et al 1998). Additionally, cannabinoids reduce hyperalgesia via inhibition of calcitonin gene-related peptide (Richardson et al 1998a). As for Substance P mechanisms, cannabinoids block capsaicin-induced hyperalgesia (Li et al 1999), and THC will do so at sub-psychoactive doses in experimental animals (Ko and Woods 1999). Among the noteworthy interactions with opiates and the endorphin/enkephalin system, THC has been shown to stimulate beta-endorphin production (Manzanares et al 1998), may allow opiate sparing in clinical application (Cichewicz et al 1999), prevents development of tolerance to and withdrawal from opiates (Cichewicz and Welch 2003), and rekindles opiate analgesia after a prior dosage has worn off (Cichewicz and McCarthy 2003). These are all promising attributes for an adjunctive agent in treatment of clinical chronic pain states.

CBD Cream

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