In this edition of Cannabis Conversations, Project CBD Director, Martin A. Lee, discusses the benefits of CBD, the "entourage effect" and the microbiome with Dr. Ethan Russo. A neurologist, scientist, and widely published author, Dr. Russo is currently the director of research and development at the International Cannabis and Cannabinoids Institute in Prague (www.icci.science).
The vast majority of CBD oils come in bottles measuring either 15 milliliters (mL), or 0.5 ounces; or 30 mL, or 1 ounce. However, CBD concentration is more important than bottle size. Concentration refers to the ratio of hemp oil solution (measured in mL) compared to the amount of CBD cannabinoid (measured in milligrams, or mg). A 15-mL bottle may contain 100 mg of CBD, 300 mg, 500 mg, or more. The higher the mg amount, the stronger the CBD oil will be. For this reason, the ‘mg’ measurement is also referred to as the oil’s strength; i.e., 400-mg oil might be called 400-strength oil.
). Hempseed oil is very rich in PUFAs ( polyunsaturated fatty acids ) which have been noted to be extremely healthy and strongly anti-inflammatory. Within about 20 weeks, the plasma lipid profiles of patients changed considerably. Their blood now contained more of healthy fats, which was doing their skin good.  Omega – 3 and omega – 6 fatty acids in hempseed oil were responsible for such an effect.
Hemp oil can be used for the treatment of minor health ailments and as a dietary supplement for the promotion of general good health. Hemp oil is considered one of the most useful natural supplements for the body due to its ability to provide essential fatty acids to humans that we would not be able to manufacture on our own. However, you should also be aware of potential side effects associated with hemp oil. As such, be sure to speak to a medical professional for more information on hemp oil effects.

Plants that qualify as industrial hemp, by the standards of the 2014 Farm Bill, must contain less than .3% THC. But the sale of hemp products is seemingly only permitted when derived from the stalks and seeds of the plant (as opposed to the flowers, where a lot of the good stuff is). Mix in the phenomenon known as the "entourage effect" — which demonstrates that CBD is most effective when used in combination with other cannabinoids, leading many to seek a "whole plant" or "full spectrum" version of the compound — and that's where it gets tricky. Are producers of hemp-derived CBD really only using stalks? Would that product be very effective? It remains unclear.
In a small study published in the journal JCI Insight in 2017, researchers observed that CBD may help prevent stress-related changes in blood pressure. For the study, nine healthy male volunteers took a single dose of either CBD or placebo. Compared to those given the placebo, those treated with CBD had lower blood pressure both before and after experiencing a stressful event.
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Our Melt is a revolutionary pain relief CBD lotion powered by Amplifi™ Nanotechnology allowing for instant relief. We were tired of coconut oil topicals that clog pores and leave skin greasy and oily, so we developed a product with a more advanced formulation. What makes Melt™ different is that it starts with organic aloe juice, making it a water-based topical lotion. So, it glides on your skin easily and absorbs rapidly, leaving no oily or sticky residue. Then, we combined cooling menthol and warming capsicum and camphor oil for that icy hot sensation. We finished with a blend of over 20 essential oils specially engineered for pain relief.
James Joliat, a 35-year-old video producer in Denver, has long experienced muscle and joint pain—mostly related to sports injuries. He says he started looking at natural remedies as an alternative to the prescription patches and pills his doctor recommended. After experimenting with homemade rubs infused with plant compounds—stuff like arnica and turmeric—he eventually stumbled onto topical cannabidiol (CBD) rubs.

Inhibited liver function: The liver regulates the way different drugs are metabolized within the body; this process is known as hepatic drug metabolism. Higher-than-average doses of CBD oil can slow the hepatic drug metabolism process. As a result, users may not be able to process other drugs as quickly. This is particularly concerning for CBD oil users who also take prescription medications.
CBD vaporizer oils can be used in a vaporizer of your choice. They offer a healthy way of inhaling your daily dose of the CBD supplement. Vaping is a very direct way of ingesting CBD oil. When you vape, the CBD enters the lungs and goes directly into the bloodstream, completely bypassing the digestive system. This method allows for greater bioavailability.

PTSD causes intense anxiety and fear, and it is caused by severe trauma (such as a frightening event, war, car accident, etc.). Whatever the cause, PTSD can cause intense stress that interferes with normal life. But thanks to the calming effect of CBD, supplementing with a CBD tincture can be a way to normalize the nervous system and reduce anxiety.
Hemp Oil Complex™ is a combination of well-balanced polyunsaturated fatty acids (PUFAs, omega-3 oil) delivering essential fatty acids needed for the formation of specialized lipid mediators for a healthy immune response. Hemp oil and omega-3 oil may support the resolution phase of the inflammatory process by providing PUFAs which are known to be precursors to endocannabinoids. Additionally, Brassica (TrueBroc®) is an important phytonutrient providing antioxidant support by activating the Nrf2/ARE pathways.
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One main asset of this serum is the scent, a dusky, spicy confluence of rich notes like spikenard, frankincense, myrrh, and lavender. These ingredients, and more, are informed by tenets of Ayurvedic and herbalist medicine, all of which are meant to complement the effects of the CBD extract with their energizing, anti-anxiety, and analgesic properties. 
Selective breeding of cannabis plants has expanded and diversified as commercial and therapeutic markets develop. Some growers in the U.S. succeeded in lowering the proportion of CBD-to-THC to accommodate customers who preferred varietals that were more mind-altering due to the higher THC and lower CBD content.[56] Hemp is classified as any part of the cannabis plant containing no more than 0.3% THC in dry weight form (not liquid or extracted form).[57]
I’ve been hoarding Girl Scouts Thin Mints lately (they’re especially good if you freeze them)—the chocolate is fine, but the peppermint oil is what makes them addicting enough to go through a whole sleeve without getting sick of them. I’m also trying to cut down on sugar, though, and while it would be a huge stretch to say that this peppermint oil-infused clear lip balm is a direct replacement for Girl Scout cookies, it really does have a very satisfying full-mouth taste of peppermint. The CBD oil, which soothes and facilitates healing at the same time, makes this formula an ideal balm for outdoor enthusiasts and or just those who are prone to painfully chapped lips. For those of us with long-hair-don’t-care, it’s not sticky—as a matter of fact, the formula is on the stiff side and won’t cause your hair to stick to your face, a welcome departure from many balms.
Overall, researchers agree that while there isn’t conclusive data to support CBD oil as the preferred method of pain management, these types of products have a lot of potential. CBD products might be able to offer relief for many people who have chronic pain, all without causing intoxication and dependence. Oil versions of CBD may not be as effective as other forms, and more human studies are needed.
CBD concentrates typically contain the strongest dosage of CBD compared to any other CBD products. It can contain up to 10 times the average CBD products. Concentrates are also convenient in that it only takes a few seconds to consume. Overall, CBD concentrates seem to be most popular among customers who are extremely busy, yet seek high potency CBD.
Common adverse events (AE) of Sativex acutely in RCTs have included complaints of bad taste, oral stinging, dry mouth, dizziness, nausea or fatigue, but do not generally necessitate discontinuation, and prove less common over time. While there have been no head-to-head comparative RCTs of Sativex with other cannabinoid agents, certain contrasts can be drawn. Sativex (Rog et al 2005) and Marinol (Svendsen et al 2004) have both been examined in treatment of central neuropathic pain in MS, with comparable results (Table 1). However, adverse events were comparable or greater with Marinol than with Sativex employing THC dosages some 2.5 times higher due to the presence of accompanying CBD (Russo 2006b; Russo and Guy 2006).

Figuring out how much CBD oil to take can feel like trying to navigate through a complicated maze. The sheer volume of CBD brands on the market can create confusion for consumers, and when you take a closer look, it’s not difficult to understand why. Not only do vendors use different source materials (CBD-rich cannabis vs. industrial hemp, different strains, etc.), but they also implement different extraction techniques .

As a patient of intermittent depression, anxiety and panic is the hard reality. When all medication failed, I was prescribed a Cannabidiol Treatment. I discovered Sera Relief CBD Oil and after reading its benefits and the fact that it was legal across the states, I was sure that this was the right supplement. The results have been amazing, reduced the arthritis and chronic pain in my wrists allowing me to perform better at my work.
In response to the FDA’s historic decision, the Drug Enforcement Administration (DEA) announced in September 2018 that it had removed Epidiolex from Schedule I classification, a category reserved for dangerous drugs with no medical value. Henceforth, Epidiolex would be considered a Schedule V drug, the least dangerous designation under the Controlled Substances Act.
They may be safe, but there's one massive problem: There's practically no scientific data to support the idea that a CBD-infused topical cream is any more effective than other topical pain relievers, like Tiger Balm, BenGay, or Icy Hot. Michelle Sexton, a San Diego-based naturopathic doctor and medical research director of the Center for the Study of Cannabis and Social Policy says that her patients do seem to have a great interest in CBD ointments, and roughly 40 percent of them have indeed tried one. However, these people are in her office now because the topicals didn’t work for them. "As a medical professional, my opinion is there’s little evidence to back up the claims being made—it’s all marketing for now," she says.
Cannador® (IKF-Berlin) is a cannabis extract administered in oral capsules, with differing figures as to THC:CBD ratios (reviewed in (Russo and Guy 2006)), generally approximately 2:1. Two pharmacokinetic studies on possibly related material have been reported (Nadulski et al 2005a; Nadulski et al 2005b). In a Phase III RCT employing Cannador in spasticity in multiple sclerosis (MS) (CAMS) (Zajicek et al 2003) (Table 1), no improvement was noted in the Ashworth Scale, but benefit was observed in spasm-associated pain on subjective measures. Both Marinol and Cannador produced reductions in pain scores in long-term follow-up (Zajicek et al 2005). Cannador was assayed in postherpetic neuralgia in 65 subjects with no observed benefit (Ernst et al 2005) (Table 1), and in 30 post-operative pain subjects (CANPOP) without opiates, with slight benefits, but prominent psychoactive sequelae (Holdcroft et al 2006) (Table 1).
I have severe neuropathy in both feet and legs. I just got the CBD oil and I am interested in learning if anyone out there has had any success with this. I know each case and pain levels are different. Just would like to see some positive remarks from people who suffer with it. I am not looking for a cure just need an update on someone who took and it helped. I already know there is no cure. I need help with the pain. Thank you.
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