I have been giving my 9 year old German Shepard the 500mg tincture a few times per day and he has really taken to it. Hes suffered from hip pain I believe arthritis and getting up off the floor and stairs have been an issue. After taking this oil We noticed immediate results. Im a believer in CBD and if Arnold could speak he would thank us for giving him this CBD. 5 stars
Cutting-edge science has shown that the endocannabinoid system is dysregulated in nearly all pathological conditions. Thus, it stands to reason that “modulating endocannabinoid system activity may have therapeutic potential in almost all diseases affecting humans,” as Pal Pacher and George Kunos, scientists with the U.S. National Institutes of Health (NIH), suggested in a 2014 publication.

Of course, though, they offer less potent oils than that, with a product lineup that ranges from 300 mg CBD per bottle to 4,000 mg. Naturally the 4,000 mg option is the most expensive (this is the one that provides the “bomb” 60 mg dose), as it currently sells for $299. For long-term pain and anxiety relief, though, it may be well worth it if it is effective for you and helps replace your regular meds.
Researchers think that CBD interacts with receptors in your brain and immune system. Receptors are tiny proteins attached to your cells that receive chemical signals from different stimuli and help your cells respond. This creates anti-inflammatory and painkilling effects that help with pain management. This means that CBD oil may benefit people with chronic pain, such as chronic back pain.
Multiple Sclerosis is a dangerous and rare condition in which nervous system degenrates. The exact cause and mechanism of this condition is still not fully known. It mostly affects young adults. A recent study [2] finds that supplementation of diet with hempseed oil and evening primrose oil improves the health of MS patients. These people were kept on a special diet containing “heating” foods, like black pepper etc. This may have something to do with the bioavailability of nutrients from these oils.
Our products include foods that are prepared in a way that safeguards their nutritional value. The majority of these ingredients are grown locally on our certified organic farm and may require chopping, dicing, juicing and/or drying for use in our products. The resulting whole food ingredients are then added to a formula that may include whole food extracts, animal tissue extracts and concentrates, botanicals, whole food isolates and synthetic ingredients. These highly complex combinations contain a variety of elements designed to trigger trophic effects that support the body’s healthy balance and wellness.*
The endocannabinoid system is tonically active in control of pain, as demonstrated by the ability of SR141716A (rimonabant), a CB1 antagonist, to produce hyperalgesia upon administration to mice (Richardson et al 1997). As mentioned above, the ECS is active throughout the neuraxis, including integrative functions in the periacqueductal gray (Walker et al 1999a; Walker et al 1999b), and in the ventroposterolateral nucleus of the thalamus, in which cannabinoids proved to be 10-fold more potent than morphine in wide dynamic range neurons mediating pain (Martin et al 1996). The ECS also mediates central stress-induced analgesia (Hohmann et al 2005), and is active in nociceptive spinal areas (Hohmann et al 1995; Richardson et al 1998a) including mechanisms of wind-up (Strangman and Walker 1999) and N-methyl-D-aspartate (NMDA) receptors (Richardson et al 1998b). It was recently demonstrated that cannabinoid agonists suppress the maintenance of vincristine-induced allodynia through activation of CB1 and CB2 receptors in the spinal cord (Rahn et al 2007). The ECS is also active peripherally (Richardson et al 1998c) where CB1 stimulation reduces pain, inflammation and hyperalgesia. These mechanisms were also proven to include mediation of contact dermatitis via CB1 and CB2 with benefits of THC noted systemically and locally on inflammation and itch (Karsak et al 2007). Recent experiments in mice have even suggested the paramount importance of peripheral over central CB1 receptors in nociception of pain (Agarwal et al 2007)
Since 1929, Standard Process has been the visionary leader in whole food nutrient solutions. We apply systems thinking to holistic nutrition that empowers practitioners to transform lives. Dedicated to the whole food philosophy of our founder, Dr. Royal Lee, our goal is to carry on his mission to provide nutrients for the body that are as close as possible to how they are found in nature.

To whom my comment is relevant: I have bipolar type 2, so my mood will cycle from major depression to “feeling well” in periods lasting about a week. CBD oil, taken orally as a spray, only seems to help if I am experiencing anxiety while in my “normal” mood. While intensely suffering, vaporizing marijuana offers a moderately helpful, temporary relief. I still cannot do my math or physics homework after using marijuana, but I can’t do much of anything besides exist while severely depressed/anxious, so I am grateful to live in a time and place where access to marijuana is safe and readily available.
I have idiopathic peripheral neuropathy ... the only thing they found that would work is lyrica. I picked up some CBD oil yesterday morning. I am prescribed to take 75 mg of lyrica 3x per day. I took one yesterday morning and have only used the CBD oil since. I bought the Koi brand, flavored, 250 MG. I used a full dropper yesterday late morning and a full dropper yesterday late afternoon. I used it once today (one full dropper) and I am amazingly pain free.
^ Hayakawa K, Mishima K, Nozako M, Ogata A, Hazekawa M, Liu AX, Fujioka M, Abe K, Hasebe N, Egashira N, Iwasaki K, Fujiwara M (March 2007). "Repeated treatment with cannabidiol but not Delta9-tetrahydrocannabinol has a neuroprotective effect without the development of tolerance". Neuropharmacology. 52 (4): 1079–87. doi:10.1016/j.neuropharm.2006.11.005. PMID 17320118.
Kats Botanicals provides excellent quality CBD derivatives including CBD Oil for Sale, CBD Vape Oil (Hemp), CBD Gummies (Hemp), and CBD isolate, which you can safely consume. Elevate your mind and body with our all natural hemp oil based products. Kats Botanicals offers a wide variety of options for wellness-minded individuals who are looking for a more naturalistic approach to their daily lives. Have you always wanted to try hemp oil? Perhaps you have a question we can answer about this amazing botanical? Introduce your mind and body to this wonderful plant called hemp, it’s molecular characteristics are called CBD, and you will enjoy a wellness minded lifestyle naturalistic evangelicals are benefitting from on a daily basis.
when i get high all i can think about is smelling my wifes slightly sweaty ass hole . I like that tight little pig skin a bit lubed up as i rub my nose around it , rimming her little hole with it . I like to suck on her pussy as i fuck her in and out with my nose , i have a good beak for this , perfect for burying inside her shit pipe deep and fucking her warm walls
I have lower back pain with some arthritis and arthritis in my hands.ive recently tried CBD Oil. It really does work. I have the drops and ointment. They both work. Because of the back pain I never would have been able to go on a hike with my family. We had a lot of fun. And "No Pain", all day. I'm also Type 2 diabetic. Anxious to see what my A1C is next month. I'm a believer.
As the PeaceHealth website suggests, hemp oil derives from a plant that contains high levels of the neurological chemical THC. This chemical can cause hallucinations, euphoria or high anxiety in supplement users when taken on a regular basis. As such, hemp oil supplements can cause similar effects in some patients using the herb for the treatment of any disorder. It is recommended that supplement users not take hemp oil products prior to operating machinery or driving due to the risk of these hallucinogenic properties. This is especially true to individuals who are overly-sensitive to THC, which can be determined by visiting your medical doctor for more information.
My mom has terminal metastatic breast cancer and her bone metastases are incredibly painful. Not only does this product keep her pain tolerable but it has also decreased her depression and anxiety significantly. She no longer has those ups and downs but finally feels GOOD. Thank you for giving my mom her quality of life back so we can truly enjoy our time with her. For reference she takes 1000 mg 2xday.
“Cannatonic” is one known popular CBD-rich strain which is known to contain 6.5% CBD by weight, and the same amount of THC, making for one of the most medicinal strains out there. Sour Tsunami, Ghost Rider, Harlequin, Jamaican Lion and Omrita Rx3 have been tested several times by several labs as high as 18% CBD with equal or lower percentages of THC (3:2 ratio of CBD to THC in most cases).
Does anybody know about cbd vs thc for chronic exhaustion? There are times that I can barely get out of bed and can’t do work due to it, and it has gotten my mood swings to go over the roof! I don’t have much interest in doing just thc because it makes me feel more lethargic, but cbd has seem to be able to help me! I need to know if someone has used it for this problem, and is results
To use CBD for pain you will find that the application process is quite easy. If you are having pain that is in your skin, muscles, or nerves that are near the skin level, you can simply rub a few CBD drops into your skin and you will feel the effects of pain relief almost instantaneously. It doesn’t take a whole lot of effort for this to have the positive effects you are looking for.

I’ve found the physical sensation of this one — warm and a little tingly, thanks to additives like nettle — is especially comforting in-flight, since I have a tendency to get goosebumps in that over-air-conditioned environment. Plus, unlike other CBD skin oils that typically come with an eye dropper, this one has a nice pump bottle. (I also have a tendency to spill all over myself, on planes and in daily life).
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Zuardi, A. W., Crippa, J. A., Hallak, J. E., Bhattacharyya, S., Atakan, Z., Martin-Santos, R., … & Guimarães, F. S. (2012). A critical review of the antipsychotic effects of cannabidiol: 30 years of a translational investigation [Abstract]. Current Pharmaceutical Design, 18(32), 5,131–5,140. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/22716160
Anecdotal evidence from patients is becoming increasingly widespread as well. Morgan Freeman suffers from pain and he was quoted saying, “I have fibromyalgia pain in my arm and the only thing that offers any relief is marijuana.” Whoopi Goldberg also uses cannabis to treat her daily pain from glaucoma and has even launched a line of medical cannabis products geared towards women suffering from menstrual pain.
Understanding CBD’s analgesic, or pain-relieving, interactions with the ECS can shed light on CBD’s other interactions and effects. Importantly, the ECS participates in our bodies’ pain processing, but when CBD is introduced to our ECS, it stops the body from absorbing a pain-regulating compound known as anandamide — one of our body’s’ own natural cannabinoid molecules. Inhibiting the absorption of this compound shunts excess quantities into the bloodstream that in turn reduces pain. One study has revealed that CBD targets alpha-3 (α3) glycine receptors to suppress chronic pain and inflammation associated with dysfunctional glycine receptors, which are an important target for pain processing in the spine. In both humans and animal models, CBD has been shown to have a variety of anti-inflammatory properties.
Phytocannabinoid-rich hemp oil has a higher concentration of CBD compared to other cannabinoids. When ingested, CBD interacts with our body’s endocannabinoid system. This triggers the body to consume more of its own cannabinoids, which directly influences our immune system—where the majority of CBD receptors are found. This helps reduce inflammation and pain and promotes a healthier immune system.
CBD has powerful effects on the liver as well. Have you ever had a prescription that warns you not to take the medicine along with grapefruit? That’s because grapefruit inhibits certain drug-metabolizing enzymes in your liver, resulting in much higher levels of your medication in your bloodstream. CBD does the same thing, so it is wise to discuss your medication regimen with a doctor or pharmacist before engaging in CBD therapy.
The glutamatergic system is integral to development and maintenance of neuropathic pain, and is responsible for generating secondary and tertiary hyperalgesia in migraine and fibromyalgia via NMDA mechanisms (Nicolodi et al 1998). Thus, it is important to note that cannabinoids presynaptically inhibit glutamate release (Shen et al 1996), THC produces 30%–40% reduction in NMDA responses, and THC is a neuroprotective antioxidant (Hampson et al 1998). Additionally, cannabinoids reduce hyperalgesia via inhibition of calcitonin gene-related peptide (Richardson et al 1998a). As for Substance P mechanisms, cannabinoids block capsaicin-induced hyperalgesia (Li et al 1999), and THC will do so at sub-psychoactive doses in experimental animals (Ko and Woods 1999). Among the noteworthy interactions with opiates and the endorphin/enkephalin system, THC has been shown to stimulate beta-endorphin production (Manzanares et al 1998), may allow opiate sparing in clinical application (Cichewicz et al 1999), prevents development of tolerance to and withdrawal from opiates (Cichewicz and Welch 2003), and rekindles opiate analgesia after a prior dosage has worn off (Cichewicz and McCarthy 2003). These are all promising attributes for an adjunctive agent in treatment of clinical chronic pain states.
The chemical difference has to do with the presence or absence of certain enzymes. Both marijuana and hemp contain a chemical substance called cannabigerol (CBGA), which is concentrated mostly in the flower buds of the plant. Marijuana contains an enzyme that converts CBGA into THC; hemp contains a different enzyme that converts CBGA into CBD (cannabidiol).

Cannabinoids, including cannabidiol (CBD), work by mimicking natural endocannabinoids like anandamide (described above) in the body. Endocannabinoids are part of a complex messaging system in the body called the endocannabinoid system. The endocannabinoid system oversees or regulates parts of the nervous system, endorphins, immune system functions, hormones, mood and emotions, metabolism, and many other chemical messengers in the body.
For our review of the best CBD topicals available online, we focused only on companies which make third-party, independent lab results available to consumers. Lab results are available online, included in the order, or on request. It’s vitally important that consumers know exactly what products they’re consuming: how strong it is, and whether it has any impurities. We also focused on brands with fast, friendly customer service and easy to use websites.

I recommend CBD International to everyone I know who is fighting cancer including the Hospice team taking care of my daughter. All the different nurses always ask, they have many patients asking. If I can save anyone the three months it took me to find you, that time saved could save a life. When you find yourself in a situation like a cancer diagnosis, you are searching for something to help, you really don't know what you are getting. My visits to the medical marijuana shops in Southern California left me frustrated, they are not knowledgeable and kept steering me to edibles and hash oil and trying to find the correct treatment was for me, about the only thing I could do for my daughter that might help her and the only thing she was willing to try. From the very first contact on your website, to the questionnaire to all correspondence, so timely and the integrity and kindness you and your company have shown me, I can't praise you enough. You guys are the real deal.

In New York City, the Department of Health announced that it had begun a crackdown on establishments (e.g., restaurants and coffee shops) that have been using CBD as a food additive. This crackdown has included seizure of CBD products, and the warning of fines to come, which could total up to $650 beginning in July for violations, according to the New York Post. According to New York City's spokesperson: "Restaurants in New York City are not permitted to add anything to food or drink that is not approved as safe to eat. Until cannabidiol... is deemed safe as a food additive, the department is ordering restaurants not to offer products containing CBD."
The hemp oil contains a number of fatty acids which are very healthy for your skin. These fatty acids nourish and moisturize your skin in the right manner and sufficient amount. There are many skin products like face creams and body creams which have hemp oil as the main ingredients. This is because it is herbal and has almost no side effects. A skin massage of only hemp oil, would give you healthy and rich skin which looks very young and held. If you are a regular user of hemp oil products for the natural skin care, it acts as an anti-aging benefit too. Hemp oil prevents skin disorders like psoriasis, eczema, acne and dry skin.
"It's important to know that the research in this area is in its infancy, partly because we haven't really understood much about CBD until relatively recently," said Marcel Bonn-Miller, an adjunct assistant professor at the University of Pennsylvania Perelman School of Medicine. He pointed out that the classification of marijuana as a Schedule 1 drug by the DEA makes it difficult to get material to use in laboratory studies. Schedule 1 drugs have a high potential for abuse, according to the DEA, and are illegal under federal law.
However, switching to CBD oil from a conventional medication is far from a random stab in the dark. In fact, there was a large scale (and very well-documented) survey carried out less than two years ago that looked at precisely what percentage of patients were able to “swap” their side effect-inducing meds for a 100% natural, cannabis-based therapy.
What makes CBD so appealing is that it’s non-intoxicating, so it won’t get you high, though it “is technically psychoactive, because it can influence things like anxiety,” Jikomes said. Although much of the marketing blitz around CBD centers on the fact that you can take it without getting stoned, there isn’t much research looking at the effects of CBD when used in isolation, with a couple of exceptions. One is the use of CBD to treat seizures: CBD is the active ingredient in the only cannabis product that the Food and Drug Administration has signed off on — a drug called Epidiolex, which is approved for treating two rare forms of epilepsy. Animal models and a few human studies suggest that CBD can help with anxiety, but those are the only conditions with much research on CBD in isolation.
In general, the majority of people end up using higher-strength products for pain than they would for things like anxiety, stress, or depression. The majority of today’s best CBD oil manufacturers offer tinctures in three different “potencies,” usually in 100, 300, or 600 mg options. Many people start on a middle ground with a 300 mg option, and work your way up from there, but it is extremely important to consult with the brand you are purchasing from before consumption.
Locsta....I share your pain of degenerative and bulging disk disease, along with fibromyalgia, chronic fatigue and arthritis. Absolutely no energy and chronic pain all day, every day. I'm curious as to what type and brand of the CBD oil you are taking and for how long have you been using it? I've been researching CBD oil for months and am quite confused!
If you haven’t been bombarded with CBD marketing or raves about it from friends, get ready. This extract—which comes from either marijuana or its industrial cousin, hemp—is popping up everywhere. There are CBD capsules, tinctures, and liquids for vaping plus CBD-infused lotions, beauty products, snacks, coffee, and even vaginal suppositories. Already some 1,000 brands of CBD products are available in stores—and online in states that don’t have lenient cannabis laws. This is a tiny fraction of what’s to come: The CBD market is poised to exceed $1 billion by 2020, per the Chicago-based research firm Brightfield Group.
There are thousands of unique varieties of hemp. The cultivars used for CBD oil contain significantly higher concentrations of CBD than others. Using these uniquely potent plants, it is possible to extract cannabis oil that contains significant levels of cannabidiol, as well as essential vitamins, minerals, fatty acids, terpenes, flavonoids, and other non-psychoactive cannabinoids.
This is one of the most informative articles I’ve read so far. I deal with GAD on a daily basis and was looking for an alternative solution. It is terrible. There are days that I don’t even want to get out of bed. I stumbled upon CBD a few months ago and honestly I can’t believe how well it works. It’s not a cure but I am definitely sleeping better and have a more positive outlook. I can feel a difference!
I have lower back pain with some arthritis and arthritis in my hands.ive recently tried CBD Oil. It really does work. I have the drops and ointment. They both work. Because of the back pain I never would have been able to go on a hike with my family. We had a lot of fun. And "No Pain", all day. I'm also Type 2 diabetic. Anxious to see what my A1C is next month. I'm a believer.
In a SAFEX study of Phase III double-blind RCT in 160 subjects with various symptoms of MS (Wade et al 2004), 137 patients elected to continue on Sativex after the initial study (Wade et al 2006). Rapid declines were noted in the first twelve weeks in pain VAS (N = 47) with slower sustained improvements for more than one year. During that time, there was no escalation of dose indicating an absence of tolerance to the preparation. Similarly, no withdrawal effects were noted in a subset of patients who voluntarily stopped the medicine abruptly. Upon resumption, benefits resumed at the prior established dosages.
Sufferers of chronic pain owe it themselves to try this product. CBD oil has been a God sent miracle. I suffer from nerve/muscle pain from my L5/S1 disc being in my spinal canal instead of between the vertebrae. For 5 years I limited my activities down to almost nothing to avoid pain. At 35, being a runner/road cyclist that was very active and in great shape, that was devastating not only to my fitness level but also my emotional and mental state. Opioids did nothing for the pain and just produced unwanted side effects. About a month or two ago, a friend got me to try pure CBD oil and within 2 days I was able to tell a difference. No shooting pains down my back/butt/leg/foot. Less muscle cramping and discomfort. The only side effect Ive had so far has been softer bowel movements and I notice I go twice a day instead of once. Ill take that over liver issues/constipation/etc with pharmaceutical company drugs every time. I was able to do yard work back to back days without issue. I was able to go bowling and shopping for hours walking around without consequence. Ive been taking it daily, three times a day (anywhere from 0.25ml to 0.5ml each dose) and it keeps me 90% pain free. I rediscovered my mouth was capable of a smile instead of a grimace. This oil doesnt cure my affliction as it treats symptoms of pain/inflammation but its given me my life back. Im grateful every single day for this product!
The CBD is often also the "city centre" or "downtown", but this is also often not the case. Midtown Manhattan is the largest central business district in New York City and in the world; yet Lower Manhattan, commonly called Downtown Manhattan, represents the second largest distinct CBD in New York City and is geographically situated south of Midtown. For example, London's "city centre" is usually regarded as encompassing the historic City of London and the mediaeval City of Westminster, whereas the City of London and the transformed Docklands area are regarded as its two CBDs. Mexico City also has a historic city centre, the colonial-era Centro Histórico, along with two CBDs: the mid-late 20th century Paseo de la Reforma - Polanco, and the new Santa Fe.

The hemp oil contains a number of fatty acids which are very healthy for your skin. These fatty acids nourish and moisturize your skin in the right manner and sufficient amount. There are many skin products like face creams and body creams which have hemp oil as the main ingredients. This is because it is herbal and has almost no side effects. A skin massage of only hemp oil, would give you healthy and rich skin which looks very young and held. If you are a regular user of hemp oil products for the natural skin care, it acts as an anti-aging benefit too. Hemp oil prevents skin disorders like psoriasis, eczema, acne and dry skin.


CBD Isolate is the purest supplement available. It’s a 99% pure CBD supplement derived from hemp oil. Despite its concentration, CBD isolate effects are similar to other CBD concentrates, and it can be used in a variety of ways. It can be consumed itself, added to foods and beverages, or vaporized. You can also add it to other CBD products to increase their potency.
Plants that qualify as industrial hemp, by the standards of the 2014 Farm Bill, must contain less than .3% THC. But the sale of hemp products is seemingly only permitted when derived from the stalks and seeds of the plant (as opposed to the flowers, where a lot of the good stuff is). Mix in the phenomenon known as the "entourage effect" — which demonstrates that CBD is most effective when used in combination with other cannabinoids, leading many to seek a "whole plant" or "full spectrum" version of the compound — and that's where it gets tricky. Are producers of hemp-derived CBD really only using stalks? Would that product be very effective? It remains unclear.

^ Hayakawa K, Mishima K, Hazekawa M, Sano K, Irie K, Orito K, Egawa T, Kitamura Y, Uchida N, Nishimura R, Egashira N, Iwasaki K, Fujiwara M (January 2008). "Cannabidiol potentiates pharmacological effects of Delta(9)-tetrahydrocannabinol via CB(1) receptor-dependent mechanism". Brain Research. 1188: 157–64. doi:10.1016/j.brainres.2007.09.090. PMID 18021759.
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