The 3000 tincture has been very helpful for me with: chronic & acute wide spread pain, headaches, anxiety, sleep, nausea, & allergies....not a complete cure, but a tremendous help with all of these, & with absolutely no side effects (& I am extremely susceptible to any side effects from meds & some supplements)....very happy to have found this product.
CBD oil contains CBD (and often other active compounds) in a carrier oil. There are a number of forms of CBD oil, including softgel capsules, tinctures, and under-the-tongue sprays. Some forms of CBD oil can also be applied directly to the skin, in the form of products like creams and salves. The concentration of CBD varies from product to product.
A. While the agency is aware of reports of pets consuming various forms of marijuana, to date, FDA has not directly received any adverse event reports associated with giving marijuana to animals via our safety reporting portals. However, adverse events from accidental ingestion are well-documented in scientific literature. If you feel your animal has suffered from ingesting marijuana, we encourage you to report the adverse event to the FDA. Please visit Reporting Information about Animal Drugs and Devices to learn more about how to report an adverse event related to an animal food or drug.
I just started taking CBD oil , I am on my 2nd Hip replacement surgery due to device failures looking at a 3rd surgery. Has you can imagine the pain, stress and anxiety levels are off the charts. Especially at an otherwise healthy 54 yr women. So i understand from reading posts its best to take it under the tongue. I am taking 1-2 ml a day. I can tell some difference,is your recommended dosage. I am using for pain , stress and sleep. I appreciate your feedback.

Did you know that the number one reported condition for medical marijuana cards is pain? In Colorado, 92% of patients, over 86,000 people, use cannabis to treat their chronic pain. Research on CBD and pain management has shown great promise and people are increasingly turning to cannabinoid therapy as the harms of opioids garner more attention and scrutiny.


I’ve been making a healing cream with CBD oil and other natural oils, so far my customers love it, they claim healing and pain relief. Healing of open wounds with hematoma symptoms erased and zero scabing. Healing psoriasis, eczema with skin returning to a renew elastic softness to skin and no flare ups. I made it for diabetes nephropathy and numbing in my feet. I have a 6 month old tummy tuck, with relief in scar tissue pain.

Even more intriguing: CBD also influences many non-cannabinoid receptor systems in the brain, interacting with receptors sensitive to a variety of drugs and neurotransmitters (Figure 2). These include opioid receptors, known for their role in pain regulation. Opioid receptors are the key targets of pharmaceutical pain killers and drugs of abuse such as morphine, heroin, and fentanyl. CBD can also interact with dopamine receptors, which play a crucial role in regulating many aspects of behavior and cognition, including motivation and reward-seeking behavior.
Dr. Waldman says it is worth trying, at least for that neurological pain, but you’ll want to follow a few precautions considering dosage is hard to decipher. “Try only one new treatment at a time, so that any effects or side effects can be attributed to the right one,” he says. Then, “start low and go slow. That is, begin with the lowest dose, used once daily, and if tolerated and necessary, the dose could be increased slowly and deliberately. It is more difficult to gauge the effects of a new treatment if it is used irregularly.” One last important note is, of course, talk to your doctor first before trying.
In this edition of Cannabis Conversations, Project CBD Director, Martin A. Lee, discusses the benefits of CBD, the "entourage effect" and the microbiome with Dr. Ethan Russo. A neurologist, scientist, and widely published author, Dr. Russo is currently the director of research and development at the International Cannabis and Cannabinoids Institute in Prague (www.icci.science).
Cannabidiol (CBD), a non-psychoactive segment of the marijuana plant, has created huge enthusiasm among researchers and physicians.  CBD Oil applies its remedial effect on an atomic level is as yet being sorted out. Cannabidiol is a pleiotropic sedate in that it produces numerous impacts through various atomic pathways. CBD Oil acts through different receptor-free channels and by official with various non-cannabinoid receptors and particle channels.
These are one of the most popular (and effective) choices for arthritis and other forms of localized pain and inflammation. Since the skin acts as an excellent semi-permeable membrane that “let’s the good stuff and keeps the bad stuff out,” rubbing CBD-infused creams into the affected area has proved to be quite effective in terms of both pain and inflammation reduction.
To calculate the cost per milligram of CBD, simply divide the dollar amount of the product by the total milligrams of CBD in the bottle. So for instance, a product with 600 mg CBD in a 1 fluid-ounce bottle costing $80 is equal to about 13 cents per mg of CBD; a product with 100 mg of CBD in the same size bottle selling for $40 works out to 40 cents per mg of CBD. In this case, it pays to splurge on the $80 bottle.

Preliminary research indicates that cannabidiol may reduce adverse effects of THC, particularly those causing intoxication and sedation, but only at high doses.[22] Safety studies of cannabidiol showed it is well-tolerated, but may cause tiredness, diarrhea, or changes in appetite as common adverse effects.[23] Epidiolex documentation lists sleepiness, insomnia and poor quality sleep, decreased appetite, diarrhea, and fatigue.[2]


Weight plays a role in the effects of CBD oil, and bottle size should be selected based on how much you weigh. Let’s say you weigh less than 130 pounds and desire light CBD oil effects; this means that 11 mg or less will probably suffice per dose, giving roughly 40 doses from a 450-mg concentration. If you weigh more than 230 pounds and desire strong effects, then this same concentration will supply roughly 10 doses. 
For anybody with chronic pain, some forms of body contact can cause intense pain, which may lead some people to avoid being touched. If left unchecked, this can turn into a serious problem that affects your personal and social life. What makes CBD perfect for pain is that it works in the central nervous system to reduce intense feelings of pain and encourage more positive feelings through the release of certain chemical compounds and the workings of CB2 receptors. Once you start using CBD, you will be more receptive to touch, and this will be a positive thing.
The FDA relies on applicants and scientific investigators to conduct research. Our role, as outlined in the Federal Food, Drug, and Cosmetic Act, is to review data submitted to the FDA in a marketing application to determine whether a proposed drug product meets the statutory standards for approval. Additional information concerning research on the medical use of marijuana is available from the National Institutes of Health, particularly the National Cancer Institute (NCI) and NIDA.
Those warning letters aside, there’s not a lot of federal oversight right now over the claims being made or the products that are being sold. Cohen warned against buying CBD products online, because “there’s a lot of scams out there.” Yet his clinic sells CBD, and he admits, “I say ‘Don’t buy online,’ but ours is worth doing, because we know what we’re doing. We ship all over.”
In a SAFEX study of Phase III double-blind RCT in 160 subjects with various symptoms of MS (Wade et al 2004), 137 patients elected to continue on Sativex after the initial study (Wade et al 2006). Rapid declines were noted in the first twelve weeks in pain VAS (N = 47) with slower sustained improvements for more than one year. During that time, there was no escalation of dose indicating an absence of tolerance to the preparation. Similarly, no withdrawal effects were noted in a subset of patients who voluntarily stopped the medicine abruptly. Upon resumption, benefits resumed at the prior established dosages.
Some research suggests that CBD also eases pain by engaging glycerin receptors – which are part of the central nervous system and are located in different parts of the brain and spinal cord. If a person has chronic pain, inflammatory factors sometimes disable these receptors, leading to higher sensation of pain, but it’s possible to reactivate them using CBD.
Have you ever been sitting on the couch thinking, “I should be doing yoga, but it just hurts too much!” It’s easy for others to casually suggest that yoga would heal your body, not realizing that the challenge is bigger than just motivation or time. High levels of pain make stretching, and sometimes even breathing, extremely difficult. CBD’s pain-relieving, and anti-inflammatory effects make yoga easier! I don’t know about you, but if something doesn’t hurt, I’m a lot more likely to do it. For conditions like Ankylosing Spondylitis, movement is essential: it slows progression of arthritic fusion.
And the final nail in industrial hemp’s proverbial coffin: Federal law in the United States prohibits the use of hemp leaves and flowers to make drug products. That said, isolating CBD nullifies these distinctions, rendering its source irrelevant as CBD isolate contains nothing but CBD. In this case, the differences between industrial hemp and whole-plant marijuana are far less significant.
CBD concentrates typically contain the strongest dosage of CBD compared to any other CBD products. It can contain up to 10 times the average CBD products. Concentrates are also convenient in that it only takes a few seconds to consume. Overall, CBD concentrates seem to be most popular among customers who are extremely busy, yet seek high potency CBD.
Scientific and clinical studies indicate that CBD could be effective in easing symptoms of a wide range of difficult-to-control conditions, including: rheumatoid arthritis, diabetes, alcoholism, PTSD, epilepsy, antibiotic-resistant infections and neurological disorders. CBD has demonstrated neuroprotective effects, and its anti-cancer potential is currently being explored at several academic research centers in the U.S. and other countries.
People all over the country love to buy CBD Oil Lotions because they perform double duty. Not only do they help to smooth and soften the skin where its placed, they also allow you to administer the cannabidiol, or CBD, directly to the area where you want it. Many people swear by their CBD Oil Lotion. While the FDA prevents us from making any health claims, we can definitely tell you that many people buy them regularly for their arthritis or aging aching joints.

Generalized pain, for instance, has dozens upon dozens of high profile research and clinical studies that have been carried out in universities and laboratories around the globe. One of the most well-publicized of these studies took place back in 2008, in which results determined that “cannabinoid analgesics (pain relievers) have generally been well tolerated in clinical trials … with acceptable adverse event profiles (meaning acceptable effectiveness for practical use).
We are staunch advocates of CBD and its many, amazing, scientifically-backed uses. We are also staunch advocates of our patrons and their access to the highest quality, 100% organic CBD products around. Getting the information you need, the exact product you want, and a no hassle transaction with no attached shipping charges – that’s what we are all about.
Healthy fats are those which contain polyunsaturated and monounsaturated fats. Due to hemp oil’s high concentration of GLA, regular consuming may be helpful for those who do not eat fish or eggs to reach their recommended daily intake of healthy fat. Research has found that having a diet high in healthy fats can improve sensitivity to insulin and stabilize heart rhythm.

Very few randomized controlled trials (RCTs) have been conducted using smoked cannabis (Campbell et al 2001) despite many anecdotal claims (Grinspoon and Bakalar 1997). One such study documented slight weight gain in HIV/AIDS subjects with no significant immunological sequelae (Abrams et al 2003). A recent brief trial of smoked cannabis (3.56% THC cigarettes 3 times daily) in HIV-associated neuropathy showed positive results on daily pain, hyperalgesia and 30% pain reduction (vs 15% in placebo) in 50 subjects over a treatment course of only 5 days (Abrams et al 2007) (Table 1). This short clinical trial also demonstrated prominent adverse events associated with intoxication. In Canada, 21 subjects with chronic pain sequentially smoked single inhalations of 25 mg of cannabis (0, 2.5, 6.0, 9.5% THC) via a pipe three times a day for 5 days to assess effects on pain (Ware et al 2007) with results the authors termed “modest”: no changes were observed in acute neuropathic pain scores, and a very low number of subjects noted 30% pain relief at the end of the study (Table 1). Even after political and legal considerations, it remains extremely unlikely that crude cannabis could ever be approved by the FDA as a prescription medicine as outlined in the FDA Botanical Guidance document (Food and Drug Administration 2004; Russo 2006b), due to a lack of rigorous standardization of the drug, an absence of Phase III clinical trials, and pulmonary sequelae (bronchial irritation and cough) associated with smoking (Tashkin 2005). Although cannabis vaporizers reduce potentially carcinogenic polyaromatic hydrocarbons, they have not been totally eliminated by this technology (Gieringer et al 2004; Hazekamp et al 2006).

No. Even in high doses, CBD oil will not cause euphoria or impair coordination, balance, or motor functions. Psychoactive effects start at 3-5% THC; CBD products contain less than 0.3% THC. Use of CBD oil is associated with improved sense of well-being, but not an exaggerated feeling of well-being. Use of CBD oil has never been associated with hallucinations or abnormal mental activity.

For anybody with chronic pain, some forms of body contact can cause intense pain, which may lead some people to avoid being touched. If left unchecked, this can turn into a serious problem that affects your personal and social life. What makes CBD perfect for pain is that it works in the central nervous system to reduce intense feelings of pain and encourage more positive feelings through the release of certain chemical compounds and the workings of CB2 receptors. Once you start using CBD, you will be more receptive to touch, and this will be a positive thing.


Frequent questions have been raised as to whether psychoactive drugs may be adequately blinded (masked) in randomized clinical trials. Internal review and outside analysis have confirmed that blinding in Sativex spasticity studies has been effective (Clark and Altman 2006; Wright 2005). Sativex and its placebo are prepared to appear identical in taste and color. About half of clinical trial subjects reported previous cannabis exposure, but results of two studies (Rog et al 2005; Nurmikko et al 2007) support the fact that cannabis-experienced and naïve patients were identical in observed efficacy and adverse event reporting
Thapa, D., Toguri, J. T., Szczesniak, A. M., & Kelly, A. E. M. (2017, April 1). The non-psychoactive phytocannabinoid, cannabidiol (CBD), and the synthetic derivatives, HU308 and CBD-DMH, reduces hyperalgesia and inflammation in a mouse model of corneal injury [Abstract]. FASEB Journal. Retrieved from https://www.fasebj.org/doi/abs/10.1096/fasebj.31.1_supplement.811.7
Hemp oil is comprised of 25 percent protein, says Dr. Andrew Weil, the program director for the Arizona Center for Integrative Medicine, which is recognized by the Arizona Board of Regents. This high-quality protein provides amino acids in ratios similar to the protein in meats and eggs. The structure of hemp oil proteins makes them easily digestible. Compared to other oils, hemp oil provides the protein and amino acids the body needs without adding unnecessary calories.
The best part about using CBD oil for pain is that you can easily find this product online or in many of the health or vitamin stores that you would visit. You can find CBD for sale in the open, meaning that you don’t need to worry about getting in trouble with the law in some capacity or another. This is a perfectly legal product for you to use, and there are many different vendors that you will find out there that offer this for sale.

If you live in a state where CBD is legal for your condition, it’s best to buy it from a state-regulated dispensary. But even there, oversight is uneven. “I feel safe being a cannabis consumer in Colorado, since the state tracks everything from seed to sale, but I didn’t the first few years after cannabis became legal,” when the rules were still taking shape, says Robyn Griggs Lawrence, the Boulder author of The Cannabis Kitchen Cookbook, which features recipes for cannabis edibles.
Chronic pain leads to a feeling of despair and hopelessness. One wonders if the pain will ever end? Will I ever get my life back? An unexpected finding during our study was that our patients were coming back to us saying they were hopeful. Instead of their glass being half empty, it was now half full. Hope is powerful. When you have hope, your mind starts to work for you instead of against you. You start to imagine that things can be different. You find the motivation to get off the couch and get busy living instead of waiting to die. This feeling of hope inspired these patients to start engaging in activities we had encouraged them to do for years, like doing yoga, eating healthier, losing weight and moving more.
For some chronic pain sufferers, a simple hug can turn into a horrible event. What is usually a comforting, therapeutic, loving gesture has layers of complexity. It hurts to be hugged, but you don’t want to say anything because it hurts the “hugger’s” feelings. Plus, you’re not sure if they’ll believe you — I mean, it sounds pretty dramatic to say you’re in so much pain you can’t tolerate a hug. Calming pain, anxiety, and the PTSD trigger response all help very much in these tough situations. Maybe with a nervous system nourished via the endocannabinoid system with CBD, you’ll be able to gently express that hugs aren’t for you.

CBD For Pets

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